POST.
MIKROBIOL.,
2003, 42,
1, 23—38
http://www.pm.microbiology.pl |
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MOLEKULARNA
CHARAKTERYSTYKA
CZYNNIKÓW WIRULENCJI
HAEMOPHILUS
INFLUENZAE
Aleksandra
Anna Zasada
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1. Wstęp.
2. Otoczka. 3. Lipooligosacharyd (LOS). 4. Fimbrie.
5. Białka Hia i Hsf. 6. Adhezyna Hap. 7. Białka
wysokocząsteczkowe (HMW). 8. Białka błony zewnętrznej
OmpP2 i OmpP5. 9. Białka wiążące hem i żelazo. 10. Tryptofanaza.
11. Proteaza IgA1. 12. Podsumowanie |
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Molecular
characterization of Haemophilus influenzae virulence
factors
Abstract:
Haemophilus influenzae is
a Gram-negative microorganism, pathogenic for human,
causing both localized respiratory tract and systemic (invasive)
disease. The initial step in the pathogenesis of disease involves
colonization of the nosopharynx. To facilitate colonization, H. influenzae
elaborates both pilus and non-pilus adhesins. To come in and
survive in dipper host tissues bacterium produces a lot of other
virulence factors that interfere with host defence mechanisms or
make possible to gain required nutrient ingradients. Because of
naturally competence for DNA uptake from environment a lot of
virulence factors were acquired through horizontal transfer and
are the pathogenicity islands. This article presents major
virulence factors of H. influenzae, their regulation
systems and mechanisms of changeability.
1. Introduction.
2. Capsule. 3. Lipooligosaccharide (LOS). 4. Fimbriae.
5. Hia and Hsf proteins. 6. Hap adhesin. 7. High
molecular weight proteins (HMW). 8. The outer membrane proteins
OmpP2 and OmpP5. 9. Heme and iron binding proteins. 10. Tryptofanase.
11. IgA1 protease. 12. Summary
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Zakład
Bakteriologii, Państwowy Zakład Higieny
ul. Chocimska 24, 00-791 Warszawa
tel. 54-21-242, e-mail: azasada@pzh.gov.pl
Wpłynęło
w sierpniu 2002 r.
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