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AKTYWNOŚĆ PRZECIWZAKAŹNA LUDZKIEJ
LEKTYNY
WIĄŻĄCEJ MANNOZĘ (MBL)
Agnieszka Cisowska1, Dorota Tichaczek-Goska1,
Waldemar Goska2
1Katedra i Zakład Biologii i Parazytologii Lekarskiej
Akademii Medycznej
ul. Mikulicza-Radeckiego 9, 50-367 Wrocław, tel. (071) 784-15-23,
e-mail:
dgoska@biolog.am.wroc.pl
2ZOZ MSWiA we Wrocławiu, Oddział Internistyczny z Salą
Intensywnego Nadzoru Kardiologicznego i
Wczesnej Rehabilitacji Kardiologicznej,
ul. Ołbińska 32, 50-233 Wrocław
Wpłynęło w listopadzie 2006 r.
1. Charakterystyka biochemiczna i genetyczna
MBL. 2. Udział MBL w aktywacji dopełniacza.
3. Wiązanie się MBL do mikroorganizmów. 4. Znaczenie
występowania niedoborów MBL w różnych chorobach. 5. Inne
funkcje MBL. 6. Podsumowanie
Anti-infectious activity of human mannose-binding lectin (MBL)
Abstract: Mannose-binding lectin (MBL) is an important
constituent of the innate immune system. It belongs to the collectin
family of proteins which are characterized
by the presence of both a collagenous region and a carbohydrate
recognition domain. In humans the proteins of this family are encoded
by a cluster of genes located on the long arm of the chromosome 10.
Low levels of MBL are caused by single nucleotide polymorphisms
within exon l or in the promoter region of the MBL-2 gene.
Such mutations have been shown to be associated with an increased
susceptibility to many infections. Absence or extremely Iow
concentration of serum MBL seems to be a risk factor for occurrence
of some disorders, in particular autoimmune diseases. MBL can bind
through multiple sites to a range of sugars including mannose, N-acetylglucosamine
and interact with a wide spectrum of bacteria, viruses, yeasts,
fungi, and protozoa decorated with such sugars. MBL bound to
microbial surfaces is able to activate complement system via the
lectin pathway. This protein may also interact directly with cell
surface receptors and thereby promote opsonophagocytosis by a
complement-independent pathway. There have been a number
reports that MBL can modulate the inflammatory response, but it is
likely that the naturę of the response is different for various
organisms or group of organisms.
1. Biochemistry and genetics of MBL. 2. MBL
as a complement activator. 3. MBL binding to
microorganisms. 4. MBL deficiency and
associated diseases. 5. Other functions of
MBL. 6. Summary
Słowa kluczowe: dopełniacz, białko wiążące mannozę, niedobory
MBL,
opsonofagocytoza
Key words: complement, mannose-binding lectin, MBL
deficiency,
opsonophagocytosis
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