TOKSYNY WĄGLIKOWE
Anna Zarzecka
Wojskowy Instytut Higieny i Epidemiologii, ul. Lubelska 2, 24-100 Puławy
Wpłynęło w styczniu 2005 r. 1. Wstęp. 2. Bacillus anthracis. 3. Toksyny wąglikowe. 3.1. PA - antygen ochronny. 3.2. LF - czynnik
letalny. 3.3. EF - czynnik obrzęku. 4. Nowe perspektywy leczenia wąglika. 5. Możliwości terapeutycznego zastosowania toksyn
wąglikowych w onkologii. 6. Podsumowanie
Anthrax toxins Abstract: Bacillus anthracis is the causative agent of anthrax. The bacterium has capsule and causes toxic effect. It secretes two toxins, which are composed of three proteins: the protective antigen (PA), the lethal factor (LF), and the edema factor (EF). PA mediates the entry of either LF or EF into the cytosol of host cell. LF is a zinc metalloprotease that inactivates mitogen-activated protein kinase kinase inducing cell death, and EF is adenyl cyclase impairing host defences. Inhibitors targeting different steps of toxin activity have recently been developed. Anthrax toxin has also been exploited as a therapeutic agent against cancer 1. Intoduction. 2. Bacillus anthracis. 3. Anthrax toxins. 3.1. PA - protective antigen. 3.2. LF - lethal factor. 3.3. EF - edema factor. 4. New perspectives of anthrax treatment. 5. The therapeutic possibilities use of the anthrax toxin in oncology. 6. Summary
Słowa kluczowe: Bacillus anthracis, toksyny wąglikowe, leczenie toksynami
Key words: Bacillus anthracis, anthrax toxin, toxins treatment
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