AKTYWACJA APOPTOZY MAKROFAGÓW
PRZEZ PAŁECZKI SALMONELLA
Grzegorz Madajczak
Zakład Bakteriologii, Państwowy Zakład Higieny ul. Chocimska 24,
00-791 Warszawa, e-mail: madajcza@wp.pl
Wpłynęło w sierpniu 2005
1. Wstęp 2. Aktywacja apoptozy makrofagów przez pałeczki
Salmonella 3. Rola białka SpvB w aktywacji procesu apoptozy 4. Podsumowanie
Macrophages apoptosis activation by Salmonella rods
Abstract: Macrophages apoptosis activation is very important element of Salmonella rods virulence. This process lets in infection spreading on whole body, simultaneously bacteria avoid immunological system. In course of Salmonella depended programmed cell death at least two ways could be favored: the early apoptosis, which occurs about 45-60 minutes after bacteria internalization into macrophage and the late programmed cell
death, which begins 12-20 hours later. For early apoptosis proteins encoded by genes localized in first
Salmonella pathogenicity island are responsible. For late apoptosis proteins encoded by genes localized in second
Salmonella pathogenicity island are responsible instead
1. Introduction. 2. Macrophages apoptosis activation by Salmonella
rods. 3. SpvB protein role in apoptosis activation. 4. Summary
Słowa kluczowe: aktywacja apoptozy, apoptoza makrofagów, białko
SpvB,
Salmonella
Key words: apoptosis activation, macrophages apoptosis, SpvB protein,
Salmonella
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