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Abstract: Skin, the largest organ in the human body, presents the largest possible area for colonization by microorganisms. The aspects of the interaction between microbiota and the host cannot be omitted during procedures in a beauty studio. Professional cosmetologists should consider their work’s impact on skin biodiversity and know the probable consequences. This review reviewed the current state of the art on skin microbiota with a focus on the connection between body area, microbiological biodiversity and the outcome of cooperation between the host and microorganisms. The role of the skin microbiota in maintaining the host’s homeostasis was also summarized.