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Abstract:  Lipopolysaccharide (LPS) is found in most Gram-negative bacteria and induces innate responses by binding to toll-like recep-tor 4 (TLR4). LPS isolated from Pantoea agglomerans species is an interesting issue. On the one hand, it is a risk factor for diseases such as wounds, abscess, bacteremia, pneumonia, urinary tract infections, septic arthritis, osteomyelitis and peritonitis. On the other, its health-promoting properties in atherosclerosis, Alzheimer’s disease, and osteoporosis are increasingly observed. Studies in humans and animal models show that LPS from P. agglomerans may have beneficial effects in the treatment of certain diseases. A huge challenge today is the prevention and treatment of skin diseases, including atopic dermatitis (AD), allergic contact dermatitis (ACD), and hard-to-heal wounds. Reports show that LPS from P. agglomerans may be useful in the treatment of skin diseases through its effects on the immune response. Studies show that LPS acts on Langerhans cells and leads to suppression of the allergic response.