1. Wstęp. 2. Właściwości biologiczne jonoforów karboksylowych i ich zastosowanie. 3. Aktywność przeciwdrobnoustrojowa naturalnych jonoforów karboksylowych i ich pochodnych. 4. Podsumowanie

Abstract: Polyether ionophore antibiotics are a large group of natural substances, produced by various species of Streptomyces. These agents possess the ability to transport metal cations across lipid membranes, interfere with natural ion transport systems in cells and exhibit a variety of biological properties (antibacterial, antiparasitic, antiinflammatory or antiacancer). Several ionophores (e.g. lasalocid, monensin, narasin, salinomycin) are commercially applied as coccidiostatics in veterinary. The purpose of this report is to present an overview of antimicrobial activities of selected ionofores – lasalocid, monensin and salinomycin, and their derivatives.

1. Introduction. 2. Biological properties of carboxylic ionophores and their application. 3. Antimicrobial activity of natural carboxylic ionophores and their derivatives. 4. Summary