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Abstract: Viral pathogens are major concern nowadays. Bacterial CRISPR/Cas systems help in defending the host body against differentpathogens including viruses too. This system contains restriction enzymes that introduce dsDNA breaks on target site to make the virusnon-functional by damaging its genes. Coronavirus, HIV and Herpes viruses are causing mortality all around the world. To control thespread of disease, early detection and treatment is required. CRISPR system due to its high efficiency provides a platform to restrictthe viral entry into host cell, viral genome editing and eliminate the latent infections. In this review, the CRISPR strategies against threemajor viral diseases are put under consideration: Coronavirus, Acquired Immunodeficiency Syndrome and Herpesvirus associated dis-eases. Three CRISPR/Cas systems have been discussed including CRISPR/Cas12, CRISPR/Cas9 and CRISPR/Cas13 that are used againstthe above listed viruses.