Browsing tag: Borrelia burgdorferi


Heart disease as a late complications of zoonosis transmitted by a ticks
I. Mączka, S. Tylewska -Wierzbanowska
1. Wstęp. 2. Bartoneloza. 3. Borelioza z Lyme. 4. Gorączka Q. 5. Riketsjoza. 6. Diagnostyka. 7. Leczenie. 8. Podsumowanie
Abstract: Many bacterial species can be a cause of various heart diseases. The pathogens that trigger these disorders are very often fastidious, uncultured bacteria, such as: Borrelia burgdorferi sensu lato, Coxiella burnetii, Bartonella spp. and Rickettsia spp. The following symptoms: myocarditis, endocarditis, pancarditis, perimyocarditis, dilated cardiomyopathy (DCM), conduction and rhythm disturbances and atherosclerotic, cardiovascular and valvular disease may indicate a bacterial etiology of the disease. Detection of significant titers of specific antibodies allows to identify the origin of the disease. A research performed recently has shown the presence of Bartonella spp., B. afzeli and C. burnetii bacteria in malfunctioning human hearts. It indicates that these pathogens, occur ring in the natural environment in ticks and other wild animals, play a significant role in constation of cardiovascular diseases.
1. Introduction. 2. Bartonellosis. 3. Lyme borreliosis. 4. Q fever. 5. Rickettsial disease. 6. Diagnostics. 7. Treatment. 8. Summary

Wrażliwość krętków Borrelia burgdorferi sensu lato na antybiotyki in vitro

Susceptibility of spirochetes Borrelia burgdorferi sensu lato to antibiotics in vitro
T. Chmielewski, S. Tylewska-Wierzbanowska

1. Wstęp. 2. Hodowla i wzrost Borrelia burgdorferi sensu lato w warunkach in vitro. 3. Wrażliwość na antybiotyki Borrelia burgdorferi in vitro. 4. Podsumowanie

Abstract: Empiric therapy has been applied in the treatment of Lyme disease. This therapy is selected following the sensitivity analysis of the proposed drug in all species of bacteria which can cause a similar type of infection and on the basis of the clinical efficacy of antibiotic treatment. Established schemes based on data collected from many centers in the world, including type of antibiotic, dose and duration of his administration, and the stage and form of Lyme disease have been created. Number of in vitro methods of spirochetes susceptibility to antibiotics has been also developed. Unfortunately, the lack of standardization often makes it impossible to compare the results of MIC and MBC. Furthermore, little is known about the interactions of the various antimicrobial substances and spirochetes. There is a need for testing of clinical strains isolated from patients after treatment, which would explain the problems associated with “refractory” cases of Lyme disease. The paper presents the research on the antibiotic-spirochete interactions observed in vitro.

1. Introduction. 2. In vitro culture and growth of Borrelia burgdorferi sensu lato. 3. In vitro susceptibility of Borrelia burgdorferi sensu stricto strains to antimicrobial agents. 4. Summary

Czynniki odpowiedzialne za rozwój Lyme carditis

Factors responsible for the development of Lyme carditis
T. Chmielewski, S. Tylewska-Wierzbanowska

1. Wstęp. 2. Lyme carditis – objawy, rozpoznanie i leczenie. 3. Patomechanizm zapalenia serca. 3.1. Ruch krętków. 3.2. Chemotaksja i adhezja. 3.3. Reakcje autoimmunologiczne. 4. Podsumowanie

Abstract: Borrelia burgdorferi sensu lato spirochetes are unique in many aspects. They are the etiological agents of Lyme borreliosis, meta-zoonotic, tick-borne disease of mammals, including humans. Ixodes spp. ticks are the vector. With the exception of erythema chronicum migrant (EM), manifestations of the disease may vary depending on the genospecies of Borrelia burgdorferi sensu lato. One of the symptoms is Lyme carditis. To date, the causative factors and the mechanisms of pathogenesis have not been well-described.
Borrelia burgdorferi spirochetes are considered as one of the most invasive mammalian pathogen. They are able to move through the skin, as well as break into and out of blood vessels, easily crossing the blood-brain barrier. Genes encoding various motility forms are bound with chemotaxis signaling system which leads and coordinates motion functions. The attachment of bacteria to host cells or extracellular matrix may promote colonization and disease development. Lyme disease spirochetes encode several surface proteins including decorin binding adhesion (DbpA), which varies among strains contributing to strain-specific differences in tissue tropism. The strains demonstrating the greatest decorin-binding activity promote the greatest colonization of heart and cause the most severe carditis. Moreover, the manifestation of Lyme carditis in certain hosts may be a result of an autoimmunological reaction due to molecular mimicry between B. burgdorferi and host self-components. In mammals, infection with B. burgdorferi induces the development of antibodies which may cross-react with myosin and neural tissue.

1. Introduction. 2. Lyme carditis – symptoms, recognition and treatment. 3. Patho-mechanism of Lyme carditis. 3.1. Spirochetes motility. 3.2. Chemotaxis and adhesion. 3.3. Autoimmunological reactions. 4. Summary