Browsing tag: degradacja

Mikrobiologiczny rozkład kwasu cynamonowego i jego hydroksypochodnych

Microbiological degradation of cinnamic acid and its hydroxyl-derivatives
D. Wojcieszyńska, K. Hupert - Kocurek, U. Guzik

1. Wprowadzenie. 2. Przemiany kwasu cynamonowego i jego hydroksypochodnych w warunkach beztlenowych. 3. Rozkład kwasu cynamonowego i jego hydroksypochodnych w warunkach tlenowych. 4. Biotransformacja kwasu cynamonowego i jego hydroksypochodnych. 5. Podsumowanie

Abstract: Microbiological degradation of cinnamic acid and its hydroxyl-derivatives occurs via aerobic or anaerobic pathway. The first step in the biodegradation of these compounds, both aerobic and anaerobic, is β-oxidation. The key intermediate in this process is benzoyl-CoA. In anaerobic environment this intermediate can be transformed to acetyl-CoA, incorporated into the central metabolism. Under aerobic condition benzoyl-CoA is transformed to protocatechuate acid, gentisic acid or catechol, compounds which are cleaved by a specific dioxygenase. Many microorganisms can transform phenolic acid to an amino acid or other compounds such as which 4-hydroxybenzoic acid, amide, acetophenone, which can be used in industry.

1. Introduction. 2. Anaerobic degradation of cinnamic acid and its hydroxyl-derivatives. 3. Degradation of cinnamic acid and its hydroxyl-derivatives under aerobic conditions. 4. Bioconversion of cinnamic acid and its hydroxyl-derivatives. 5. Summary

Mikrobiologiczna degradacja niesteroidowych leków przeciwzapalnych

Microbial degradation non-steroidal anti-inflammatory drugs
U. Guzik, K. Hupert-Kocurek, D. Wojcieszyńska

1. Wprowadzenie. 2. Charakterystyka niesteroidowych leków przeciwzapalnych. 3. Degradacja niesteroidowych leków przeciwzapalnych metodami fizyko-chemicznymi. 4. Szlaki biologicznej degradacji niesteroidowych leków przeciwzapalnych. 5. Podsumowanie

Abstract: In the recent years, commonly used non-steroidal anti-inflammatory drugs (NSAIDs) are widely detected in the environment. These biologically active substances and their continuous inflow into the environment may lead to their accumulation in the environment and chronic exposure of organisms. This in turn may cause the potential negative effects on living organisms. While the transformation mechanisms of non-steroidal anti-inflammatory drugs in the human body and in other animals have been extensively studied, degradation of these drugs by bacteria (including their degradation pathways and degradation products) has seldom been investigated and are largely unknown. Therefore, the objective of this paper is presentation actual stage of knowledge about microbiological degradation pathways of NSAIDs such as naproxen, ibuprofen, diclofenac, paracetamol.

1. Introduction, 2. Characterization of non-steroidal anti-inflammatory drugs, 3. Degradation of non-steroidal anti-inflammatory drugs by physicochemical methods, 4. Pathways of biological degradation of non-steroidal anti-inflammatory drugs, 5. Conclusion