Mikrobiologiczna degradacja niesteroidowych leków przeciwzapalnych

Microbial degradation non-steroidal anti-inflammatory drugs
U. Guzik, K. Hupert-Kocurek, D. Wojcieszyńska

1. Wprowadzenie. 2. Charakterystyka niesteroidowych leków przeciwzapalnych. 3. Degradacja niesteroidowych leków przeciwzapalnych metodami fizyko-chemicznymi. 4. Szlaki biologicznej degradacji niesteroidowych leków przeciwzapalnych. 5. Podsumowanie

Abstract: In the recent years, commonly used non-steroidal anti-inflammatory drugs (NSAIDs) are widely detected in the environment. These biologically active substances and their continuous inflow into the environment may lead to their accumulation in the environment and chronic exposure of organisms. This in turn may cause the potential negative effects on living organisms. While the transformation mechanisms of non-steroidal anti-inflammatory drugs in the human body and in other animals have been extensively studied, degradation of these drugs by bacteria (including their degradation pathways and degradation products) has seldom been investigated and are largely unknown. Therefore, the objective of this paper is presentation actual stage of knowledge about microbiological degradation pathways of NSAIDs such as naproxen, ibuprofen, diclofenac, paracetamol.

1. Introduction, 2. Characterization of non-steroidal anti-inflammatory drugs, 3. Degradation of non-steroidal anti-inflammatory drugs by physicochemical methods, 4. Pathways of biological degradation of non-steroidal anti-inflammatory drugs, 5. Conclusion