Diagnostyka serologiczna i molekularna grzybic inwazyjnych

Serological and molecular diagnostic methods for invasive fungal infections
T. Dzieciątkowski, A. Sulowska, M. Przybylski

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1. Wstęp. 2. Diagnostyka serologiczna zakażeń Candida spp. 3. Diagnostyka serologiczna aspergillozy 4. Diagnostyka serologiczna kryptokokozy 5. Metody molekularne stosowane w diagnostyce grzybic inwazyjnych 6. Podsumowanie

Abstract: Various species of Candida spp. and Aspergillus spp. remain the most common cause of invasive fungal infections, but other yeasts and filamentous fungi are emerging as significant pathogens. Invasive mycoses continue to be a significant cause of morbidity, especially in transplant recipients and/or in patients undergoing long-time antibiotic therapy. A reliable and early diagnostic method of fungal infections by detecting fungal DNA or invasiveness factors, such as (1→3)-β-D-glucan or antimycelial antibodies, have proven very useful in reducing associated mortality in affected patients. This article is a review of the literature on current serological and molecular methods used in invasive fungemia diagnostics.

1. Introduction. 2. Serological diagnostics of Candida spp. infections. 3. Serological methods in diagnostics of invasive aspergillosis. 4. Serological diagnostics of Cryptococcus neoformans infections. 5. Molecular methods used in the diagnosis of invasive fungaemia. 8. Summary